Many in vitro applications for chemical-induced dimerization (CID) have progressed into transgenic animals. The B/B Homodimerizer (AP20187) has been the most widely used in vivo, and typically investigators have used doses of 0.5–10 mg per kg for each injection. At this dosage, 5 mg of dimerizer is sufficient for 20–400 injections for a 25-gram mouse. However, the exact dose and treatment must be determined empirically for each experiment.
Many in vitro applications for chemical-induced dimerization (CID) have progressed into transgenic animals. The B/B Homodimerizer (AP20187) has been the most widely used in vivo, and typically investigators have used doses of 0.5–10 mg per kg for each injection. At this dosage, 5 mg of dimerizer is sufficient for 20–400 injections for a 25-gram mouse. However, the exact dose and treatment must be determined empirically for each experiment.
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