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Clontech/EpiXplore Methylated DNA Enrichment Kit/10 Rxns/631963
产品编号:631963
市  场 价:¥0.00
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Clontech/EpiXplore Methylated DNA Enrichment Kit/10 Rxns/631963
商品介绍

The EpiXplore Methylated DNA Enrichment Kit provides a simple magnetic bead-based method for enriching and fractionating both hypo- and hypermethylated DNA from the whole genome. Enrichment leads to superior results in gene regulation studies by reducing background during sequencing.

The EpiXplore Methylated DNA Enrichment Kit provides a simple magnetic bead-based method for enriching and fractionating both hypo- and hypermethylated DNA from the whole genome. Enrichment leads to superior results in gene regulation studies by reducing background during sequencing.

Why choose the EpiXplore Methylated DNAEnrichment Kit?

  • The EpiXplore protocol is based on affinity binding between methylated DNA and Methylated DNA Binding Domain Protein 2 (MBD2).
  • It does not require any antibodies or follow an immunoprecipitation (IP) protocol.
  • Its flexible protocol allows you to elute your methylated DNA in fractions (by methylation density) or as a single fraction.

By contrast, antibody-based (IP) enrichment methods, including MeDIP, lack flexibility and the necessary pretreatments often result in loss of starting material. More importantly, antibody-based enrichment is “all or none”—that is, it does not allow gradient separation of methylated DNA.

Why fractionate by methylation density?

Recent reports indicate that regions of the genome with medium to low density methylation (including regions far from promoters and CpG islands) can play an important role in differential gene regulation. If you are looking for a comprehensive picture of methylation activity, differentiating these regions is an important first step. Only the EpiXplore Methylated DNA Enrichment Kit includes elution buffers which allow you to split your enriched methylated DNA into three fractions, based on methylation density.

How many methylated sites are required for binding?

The EpiXplore Methylated DNA Enrichment Kit contains a fragment of the MBD2 protein which provides high sensitivity. The kit can enrich DNA fragments containing as few as three methylated CpG pairs (6 total methylation sites).

Can your current enrichment method compete?

Is your enriched methylated DNA…EpiXplore protocol Antibody-based protocols
HTS-ready?YES. Enriched methylated DNA is double-stranded and ready for useNo. Enriched DNA requires further processing
Intact?YES. Uses a gentle (magnetic) separation processNo. Harsh separation conditions often lead to sample loss
Easy to elute?YES. Uses a simple buffer-based protocolNo. Elution requires multiple complex steps
Separated by methylation density?YES. Methylated DNA can be eluted in low, medium, and high density fractions or as a single fractionNo. Elution is “all or none”
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品牌介绍

美国Clontech公司是一家专门致力于基因工程及蛋白质工程领域研究用产品的研发和生产的专业公司。公司产品涉及PCR产品、RT-PCR产品、cDNA文库构建、基因克隆、基因表达、基因分析、蛋白质技术等诸多领域。产品种类多达2000多种。Clontech公司拥有多种独立知识产权产品,其强大的科研实力和完善的质量管理体系(ISO9001)为Clontech产品的良好品质提供了可靠保障。

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